Luche Reduction

Mechanism of the Luche Reduction

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Sample reactions

NaBH4, CeCl3
MeOH
0 °C, 60 min


NaBH4, CeCl3
H2O, MeOH
-78 to -50 °C, 3 h


NaBH4, CeCl3
MeOH
0 °C, 30 min, 97%


NaBH4, CeCl3
MeOH
23%
"Also isolated was the C13-epimer (67 % yield)."


NaBH4, CeCl3.7H2O
CH2Cl2, MeOH
0 °C, 70 min, 92%


NaBH4, CeCl3.7H2O
EtOH
0 °C, 30 min, 92%


NaBH4, CeCl3.7H2O
CH2Cl2, EtOH
-78 °C, , 67%


NaBH4, CeCl3.7H2O
MeOH
0 °C, 10 min, 44%
"Also isolated was the C8-epimer (53 % yield)."


NaBH4, CeCl3.7H2O
MeOH
0 °C, 4 h, 49%
"Also isolated was the C3-epimer (43 % yield)."


NaBH4, CeCl3
MeOH
RT, 5 min, 99%


NaBH4, CeCl3.7H2O
MeOH
-78 °C, 45 min, 85%


NaBH4, CeCl3.7H2O
MeOH
0 °C, 20 min, 97%
