Kumada-Corriu Coupling

Schematic representation of the Kumada-Corriu Coupling.

Mechanism of the Kumada-Corriu Coupling

Mechanism of the Kumada-Corriu Coupling

Original publication	J. Am. Chem. Soc.. 1971, 93, 1483. J. Am. Chem. Soc.. 1972, 94, 4374. J. Chem. Soc., Chem. Commun.. 1972, 144a, 0. Monatsh. Chem.. 2012, 143, 1575. J. Chem. Soc., Perkin Trans. 2. 1994, 0, 1063.
Reviews	Chem. Soc. Rev.. 2011, 40, 4948. Synthesis. 1992, 0, 413.

Sample reactions

intermediate structure

Pd(PPh3)4, TMSCH2MgCl

Et2O

RT, 60 min, 91%

intermediate structure

intermediate structure

intermediate structure

Pd(PPh3)4

THF

RT, 30 min, 62% (3 steps)

intermediate structure

intermediate structure

Pd2(dba)3, TMSCH2MgCl, t-Bu3P

THF

Reflux, 12 h, 83%

intermediate structure

intermediate structure

NaOH, Pd(PPh3)4, TMSCH2MgCl

H2O, MeOH, THF

Reflux, 75 min, 94%

intermediate structure