Krapcho Decarboxylation

Mechanism of the Krapcho Decarboxylation

Sample reactions

KI
DMF
125 °C, , 70% (2 steps)


LiCl
DMSO, H2O
170 °C, 70 min, 83%


LiCl
DMSO, H2O
140 °C, 15 min, 71% (4 steps)


LiI.3H2O
DMF
Reflux, 18 h, 85%


LiI
DMF
Reflux, 2 h, 65% (2 steps)


LiI, 2,4,6-Collidine
80 °C, 60 min


LiCl
DMSO, H2O
140 °C, 17 h, 97% (2 steps)


LiCl
DMF
135 °C, 4 h, 88% (2 steps)


LiCl, Et3N.HCl
DMA
130 °C, 2.5 h, 84%


NaCl
DMF, H2O
Reflux, 35 h, 69%


NaCl
DMF, H2O
Reflux, 35 h, 67% (2 steps)


NaCl
DMF, H2O
Reflux, 4 h, 56%


LiCl
DMSO, H2O
160 °C, 2 h, 85%


LiCl
DMF
140 °C, 3 h, 88%
