Huisgen Cycloaddition

Mechanism of the Huisgen Cycloaddition

Original publication | |
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Reviews |
Sample reactions


MeCN
RT, 5 h, 65%
"The product was cristallized to optical purity."


N-Benzylglycine
Dean-Stark
PhMe
Reflux, 15 h, 57%
"Also isolated was the C2-epimer (3 % yield)."


(CH2O)n
Sealed tube
PhMe
115 °C, 14 h, 70%


Sealed tube
THF
180 °C, 16 h, 20%
"Also isolated was 70 % of a regioisomer which could be thermally equilibrated to the desired product."


NaOEt, MeNHOH.HCl
EtOH, PhMe
Reflux, 24-36 h, 75%



HgO
PhMe
Reflux, 15 h, 96%


Xylene(s)
Reflux, 3 h


K2CO3
PhMe
130 °C, 10 h, 68% (2 steps)
