Hofmann Rearrangement

Mechanism of the Hofmann Rearrangement

Original publication	Ber. Dtsch. Chem. Ges.. 1881, 14, 2725.
Reviews	Comp. Org. Syn.. 1991, 6, 795. Org. React.. 1946, 3, 267.

Sample reactions

Pyr, PhI(O2CCF3)2

Dark

MeCN

RT, 3 h

PhI(OAc)2, AllylOH

4 Å MS

DCE

60 °C, 11 h, 88%

Pb(OAc)4

t-BuOH

50 °C, 3 h, 70%