Henry Reaction

Mechanism of the Henry Reaction

Sample reactions

Et2NH, MeNO2
EtOH
Reflux, 2.5 h, 68%


NH4OAc
MeNO2
Reflux, 60 min, 92%



(S)-BINOL, La(Ot-Bu)3
THF
-50 °C, 60 h, 73%


Et3N
MeNO2
RT, 15 h


MeNO2, NH4OAc
AcOH
Reflux, 2 h, 65%


MeNO2, Cu(OAc)2
EtOH
RT, 5 d, 69%
">99:01 e.r."



i-Pr2NLi
THF
-78 °C to RT, 2.5 h
