Sample reactions
intermediate structure
HCO2H, PdCl2.2MeCN
DMF, Et3N
60 °C, 60 min, 93%
intermediate structure
intermediate structure intermediate structure
i-Pr2NEt, Pd(OAc)2, Et3NBn+ Cl-
DMF
80 °C, , 45%
intermediate structure
intermediate structure
Et3N, Pd2(dba)3.CHCl3, Ag3PO4
THF
66 °C, 13 h, 70%
intermediate structure
intermediate structure
K2CO3, Pd(PPh3)4
MeCN
90 °C, , 46%
intermediate structure
intermediate structure
Et3N, Pd2(dba)3
DMF
140 °C, 5 h, 60%
intermediate structure
intermediate structure
Pd(CF3CO2)2(PPh3)2, 1,2,2,6,6-Pentamethylpiperidine
PhMe
120 °C, , 60%
intermediate structure
intermediate structure
Pd(OAc)2, dppp, Ag2CO3
PhMe
107 °C, 24 h, 91%
intermediate structure
intermediate structure
Pd(OAc)2, dppp, Ag2CO3
PhMe
107 °C, 4 h, 65%
"The yield was 74 % brsm."
intermediate structure
intermediate structure
Pd(OAc)2, Ph3P, Ag2CO3
PhMe
80 °C, 60 min, 66%
intermediate structure
intermediate structure
Et3N, Pd(OAc)2, Et3NBn+ Cl-
DMF
80 °C, 30 min, 66%
intermediate structure
intermediate structure
NaOAc, Pd(OAc)2, Ph3P, n-Bu4N+ Cl-
DMF, H2O
125 °C, 4 h, 84%
intermediate structure
intermediate structure
K2CO3, Pd(OAc)2, n-Bu4N+ Cl-
DMF
70 °C, 3 h, 74%
intermediate structure
intermediate structure
K2CO3, Pd(OAc)2, n-Bu4N+ Cl-
DMF
70 °C, 4 h, 68%
intermediate structure
intermediate structure
Pd(OAc)2, Ph3P
Et3N
90 °C, 2 h, 85%
intermediate structure
intermediate structure
Pd(OAc)2, Ph3P
Et3N
90 °C, 90 min, 53%
intermediate structure
intermediate structure
Pd(OAc)2, Ag2CO3, Me2PPh
DMSO
90 °C, 17 h, 87%
"Cristallized to >99:01 er (73 % yield)."
intermediate structure
intermediate structure
i-Pr2NEt, Pd(OAc)2, Ph3P
DMSO
80 °C, 90 min, 46%
intermediate structure
intermediate structure
K2CO3, Pd(OAc)2, Ph3P, n-Bu4N+ Cl-
DMF
70 °C, 30 min, 48%
intermediate structure
intermediate structure
NaHCO3, Pd(OAc)2, n-Bu4N+ Cl-
EtOAc
RT, 24 h, 58%
intermediate structure
intermediate structure intermediate structure
HCO2H, Pd(OAc)2, Ph3P, Piperidine
DMF
70 °C, 6.5 h, 35%
intermediate structure
intermediate structure
Et3N, Pd(OAc)2
PhMe
Reflux, 6 h, 87%
intermediate structure
intermediate structure
Pd(OAc)2, Ph3P, TlOAc
DMF
130 °C, 24 h, 93%
intermediate structure