Fischer Indole Synthesis

Schematic representation of the Fischer Indole Synthesis.
Mechanism of the Fischer Indole Synthesis
Mechanism of the Fischer Indole Synthesis
Sample reactions
intermediate structure intermediate structure
PPA
100 °C, 10 min, 54%
intermediate structure
intermediate structure
HCO2H
80 °C, 10 h, 72%
intermediate structure
intermediate structure
AcOH
110 °C, 40 h, 75% (93% BRSM)
intermediate structure
intermediate structure
PhNHNH2
AcOH
95 °C, 8 h, 62%
intermediate structure