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Protecting Groups
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Named Reactions
Protecting Groups
Evans Asymmetric Aldol Addition
Mechanism of the Evans Asymmetric Aldol Addition
Original publication
Pure Appl. Chem.. 1981, 53, 1109.
J. Am. Chem. Soc.. 1981, 103, 2127.
Reviews
Aldrichimica Acta. 1982, 15, 23.
Tetrahedron. 1992, 48, 2127.
Sample reactions
info
Et3N
,
n-Bu2BOTf
CH2Cl2
-78 to -40 °C, 2.5 h, 96%
info
i-Pr2NEt
,
n-Bu2BOTf
,
Acrolein
CH2Cl2
-78 to 0 °C, 90 min, 93%
info
Et3N
,
n-Bu2BOTf
CH2Cl2
-78 to 0 °C, 80 min, 86%
info
Et3N
,
n-Bu2BOTf
CH2Cl2
-78 to 0 °C, 3.5 h, 93%