Eschweiler-Clarke Reaction

Schematic representation of the Eschweiler-Clarke Reaction.
Mechanism of the Eschweiler-Clarke Reaction
Mechanism of the Eschweiler-Clarke Reaction
Original publication
Ber. Dtsch. Chem. Ges.. 1905, 38, 880. J. Am. Chem. Soc.. 1933, 55, 4571.
Review
Org. React.. 1949, 5, 301.
Sample reactions
info
intermediate structure
CH2O
H2O, HCO2H
94%
intermediate structure