Corey-Nicolaou Macrolactonization

Mechanism of the Corey-Nicolaou Macrolactonization

Original publication	J. Am. Chem. Soc.. 1974, 96, 5614. Synthesis. 2002, 2002, 1728.
Review	Tetrahedron. 1977, 33, 683.

Sample reactions

PhMe

110 °C, , 70% (3 steps)