Claisen-Schmidt Condensation

Mechanism of the Claisen-Schmidt Condensation

Sample reactions


NaOH
MeOH
RT, 48 h, 96%



H3PO4
80 °C, , 82%


(CH2O)3, PhNHMe.TFA
Dioxane
45%
"The yield was 90 % brsm."


TsOH
PhH
80 °C, , 75% (3 steps)


TsOH
PhH
Reflux, 4 h, 78%


NaOH, Dibenzo-18-crown-6
PhH
Reflux, , 96%


AcOH, Piperidine
PhMe
Reflux, 48 h, 41%



NaOH
EtOH, H2O
RT, 15 h, 83%



Mg(OMe)2
PhMe
Reflux, 2.5 h, 52%
