Blanc Halomethylation

Mechanism of the Blanc Halomethylation

Original publication	Bull. Soc. Chim. Fr.. 1923, 33, 313.
Reviews	Org. React.. 1942, 1, 63. Russ. Chem. Rev.. 1977, 46, 891.

Sample reactions

BnOCH2Cl

Sulfolane

75-80 °C

(CH2O)n, HCl

AcOH, H2O

50 °C, 24 h, 62%

(CH2O)n, H3PO4, HBr

AcOH, H2O

80 to 120 °C, 8.5 h, 51%