Bischler-Napieralski Reaction

Mechanism of the Bischler-Napieralski Reaction

Original publication	Ber. Dtsch. Chem. Ges.. 1893, 26, 1903. J. Org. Chem.. 1992, 57, 6765.
Reviews	Org. Prep. Proced. Int.. 1996, 28, 1. Org. React.. 1951, 6, 74.

Sample reactions

POCl3

Reflux, 2 h

Ac2O, HCl

H2O, HCO2H

RT to 55 °C, 16 h, 63%

POCl3

MeCN

Reflux, 70 min