Barton-McCombie Reaction
Mechanism of the Barton-McCombie Reaction
Sample reactions
AIBN, n-Bu3SnH
PhH
Reflux, 4 h, 74%
AIBN, n-Bu3SnH
PhH
Reflux, 30 min, 94%
AIBN, n-Bu3SnH
PhMe
110 °C, 4 h, 71%
AIBN, n-Bu3SnH
PhMe
110 °C, 4 h, 50% (3 steps)
AIBN, n-Bu3SnH
PhMe
72% (3 steps)
AIBN, n-Bu3SnH
PhH
90%
n-Bu3SnH
PhMe
Reflux, 6 h, 19%
AIBN, n-Bu3SnH
PhMe
Reflux, 2 h, 100%
AIBN, n-Bu3SnH
PhH
Reflux, 2 h, 70%
AIBN, n-Bu3SnH
PhMe
Reflux, 45 min, 66%
AIBN, n-Bu3SnH
Dioxane
100 °C, 20 min, 35%