Appel Reaction

Schematic representation of the Appel Reaction.
Mechanism of the Appel Reaction
Mechanism of the Appel Reaction
Original publication
Review
Sample reactions
intermediate structure
I2, Imidazole, Ph3P
88%
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
THF
0 °C, 3 h
intermediate structure
intermediate structure
Ph3P, C2Cl6
CH2Cl2, Et2O
0 °C, 60 min, 93%
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
PhMe
RT, 60 min, 90%
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
CH2Cl2
RT, 60 min, 80%
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
CH2Cl2
RT, 60 min
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
Et2O, MeCN
0 °C to RT, 70 min, 89%
intermediate structure
intermediate structure
I2, Imidazole, Ph3P
Et2O, MeCN
0 °C to RT, 2 h, 85%
intermediate structure
intermediate structure
Ph3P, Cl3CC(O)CCl3
CH2Cl2
-78 to 0 °C, 15 min, 94%
intermediate structure
intermediate structure
Br2, Ph3P
DMF, PhH
RT, 4 h, 59%
intermediate structure