Alkyne Zipper Reaction

Schematic representation of the Alkyne Zipper Reaction.
Mechanism of the Alkyne Zipper Reaction
Mechanism of the Alkyne Zipper Reaction
Original publication
J. Am. Chem. Soc.. 1975, 97, 891.
Review
Sample reactions
info
intermediate structure
KH
1,3-Diaminopropane
RT, 3 h, 71%
intermediate structure
info
intermediate structure
KH
1,3-Diaminopropane
0 °C, 60 min, 86%
intermediate structure
info
intermediate structure
KOt-Bu, Li
1,3-Diaminopropane
RT, 2 h, 93%
intermediate structure