Protecting groups

Select a protective group to get the conditions needed to install/remove the group. Several reaction samples of protection and deprotection are shown for each groups.

All of theses reactions are taken from our synthesis database and the list is continually growing.

Protection of Aldehyde, Ketone

1,3-Dithiane 1,3-Dithiolane Diethyl acetal Dimethyl acetal Ethylene glycol acetal Neopentyl glycol acetal Trimethylsilyl cyanohydrin

Protection of Indole

1-Chloroethyl carbamate (ACE) Methoxymethyl aminal (MOM) N-(4-Methoxybenzyl)indole (PMB) tert-Butoxy carbamate (Boc)

Protection of Amine

1-Chloroethyl carbamate (ACE) 4-Methoxybenzenesulfonamide Acetamide (Ac) Benzylamine (Bn) Benzyloxy carbamate (CBz) Formamide Methyl carbamate Trifluoroacetamide tert-Butoxy carbamate (Boc)

Protection of Alcohol

2,2,2-Trichloroethyl carbonate (Troc) 2-Methoxyethoxymethyl ether (MEM) 2-Naphthylmethyl ether (Nap) 4-Methoxybenzyl ether (PMB) Acetate (Ac) Benzoate (Bz) Benzyl ether (Bn) Benzyloxymethyl acetal (BOM) Ethoxyethyl acetal (EE) Methoxymethyl acetal (MOM) Methoxypropyl acetal (MOP) Methyl ether Tetrahydropyranyl acetal (THP) Triethylsilyl ether (TES) Triisopropylsilyl ether (TIPS) Trimethylsilyl ether (TMS) tert-Butyldimethylsilyl ether (TBS, TBDMS) tert-Butyldiphenylsilyl ether (TBDPS)

Protection of 1,2-Diol

Acetonide Benzaldehyde acetal Carbonate

Protection of 1,3-Diol

Benzaldehyde acetal di-tert-Butyl dioxasilinane

Protection of Carboxylic acid

Benzyl ester Methyl ester

Protection of Phenol

Benzyl ether (Bn) Methoxymethyl acetal (MOM) Methyl ether Triisopropylsilyl ether (TIPS) [2-(Trimethylsilyl)ethoxy]methyl acetal (SEM) tert-Butyldimethylsilyl ether (TBS, TBDMS)

Protection of 1,2-Aminoalcohol

Carbamate

Protection of Acetylene

Trimethylsilane (TMS)

Protection of Amide, Carbamate

tert-Butoxy carbamate (Boc)

Protection of Sulfonamide

tert-Butoxy carbamate (Boc)