Synthesis of Sylvone

Structure of Sylvone

C23H28O8

Principal investigatorTomislav Rovis
Publication year2008
Synthesis typeTotal
Number of steps 6 (linear)
References
Part 1 of 1
intermediate structure + intermediate structure
TsOH
PhH
Reflux, , 85%
intermediate structure + intermediate structure
Pd(OAc)2, Et3NBn+ Cl-, i-Pr2NEt
DMF
80 °C, , 45%
See the Heck Coupling
intermediate structure
TMSOTf
EtCN
-78 °C
intermediate structure
NaBH4
MeOH
intermediate structure
OsO4, NMO
Acetone, t-BuOH, H2O
intermediate structure
NaIO4
THF, H2O
85% (4 steps)
intermediate structure