Synthesis of [6.5]Coronane
C24H36
Principal investigator | Lutz Fitjer |
---|---|
Publication year | 1987 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
Et3N
Et2O, PhH
50 °C, 25 h, 70%
NaOMe
PhMe
Reflux, 1 h, 68%
AllylMgBr
Et2O
Reflux, 6 h, 60%
See the Grignard Reaction
"Also isolated was the equatorial alcohol (stable conformer, 17% yield)"
SOCl2
Pyr
0 °C to RT, 9 h, 92%
- Cp2ZrHCl
- NBS
PhH
RT, 3 h, 82%
AIBN,
n-Bu3SnH
PhH
80 °C, 63 h, 8%