Synthesis of Ferruginol
C20H30O
Principal investigator | Frederick E. King |
---|---|
Publication year | 1957 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
+
Na,
Fe(NO3)3
NH3
-78 °C, 75%
Pd(OH)2/CaCO3,
H2
1-3 atm
EtOH
RT, 30 min, 97%
AlCl3,
AcCl
PhNO2
5 °C, 4 d, 23%
See the Friedel-Crafts Acylation
"Purified by crystallization of the semicarbazone."
Ac2O
Reflux, 60 min, 76% (2 steps)
PtO2,
H2
EtOH
RT, 30 min, 88%
HBr
AcOH, H2O
Reflux, 14 h, 36%
"Purified by crystallization of the benzoate ester."