Synthesis of L-163007
C34H38F3N5O6S
Principal investigator | Linda L. Chang |
---|---|
Publication year | 1994 |
Synthesis type | Total |
Number of steps | 10 (3 parts) |
References |
Part 1 of 3
+
Et3N
PhMe
50 to 95 °C, ON, 58%
Part 2 of 3
+
t-BuNH2
CHCl3
RT, 12 h, 84%
Part 3 of 3
+
NaH
DMF
50 °C, 4 h, 92%
ClF2CCO2Me,
KF,
CuI
DMF
120 °C, 12 h, 37%
PtO2,
H2
4 atm
EtOAc, EtOH
RT, 100%
EtCOBr,
DMAP
Pyr
RT, ON, 90%
PhOMe
CF3CH2OH
RT, ON, 91%
NaH,
Boc2O
THF
50 °C, 22 h, 74%