Synthesis of Longifolene
C15H24
Principal investigator | Arthur G. Schultz |
---|---|
Publication year | 1985 |
Synthesis type | Formal |
Number of steps | 14 (linear) |
References |
Part 1 of 1
+
+
HCl
MeOH
ClCO2Me,
NaHCO3
HCl,
HC(OMe)3
MeOH
Reflux
NaOMe
MeOH
75% (4 steps)
NBS
MeOH
95%
DBU
PhMe
Reflux, 85%
TsOH
Acetone
Reflux, 86%
Xylene(s)
Reflux, 40% (2 steps)
Pd/C,
H2
EtOH
RT, 92%
KOH
H2O, MeOH
RT, 85%
PhMe
Reflux, 86%
Remaining...
75% (3 steps)
"See : J. Am. Chem. Soc. 1978, 100, 2583."