Synthesis of Julifloridine

Structure of Julifloridine

C18H37NO2

Principal investigatorAndré B. Charette
Publication year2005
Synthesis typeTotal
Number of steps 4 (linear)
References
Part 1 of 1
intermediate structure + intermediate structure + intermediate structure
Tf2O, LiI
CH2Cl2
-78 °C to RT, 16 h, 80%
intermediate structure
H2, Pd/C
PhMe
RT, 2 h, 71%
intermediate structure
  1. DMDO
  2. Me2Zn
THF, Acetone
-78 °C, 15 h, 73%
intermediate structure
Li
NH3, THF, EtOH
-33 °C, 3.5 h, 83%
See the Birch Reduction
intermediate structure