tert-Butyldimethylsilyl ether (TBS, TBDMS)

tert-Butyldimethylsilyl ether (TBS, TBDMS) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • TBSCl Imidazole
    DMF
    RT
    3 h
    94 %
    intermediate structure
    TBSCl, Imidazole
    DMF
    RT, 3 h, 94%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • HCl
    MeCN H2O
    RT
    3 h
    95 %
    intermediate structure
    HCl
    MeCN, H2O
    RT, 3 h, 95%
    intermediate structure