N-(4-Methoxybenzyl)indole (PMB)

N-(4-Methoxybenzyl)indole (PMB) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • (4-MeOPh)CH2Cl NaH
    DMF
    0 °C - RT
    35 min
    94 %
    intermediate structure
    (4-MeOPh)CH2Cl, NaH
    DMF
    0 °C to RT, 35 min, 94%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • PhSH
    CF3CO2H
    45 °C
    13 h
    66 %
    intermediate structure
    PhSH
    CF3CO2H
    45 °C, 13 h, 66%
    intermediate structure