Methoxymethyl aminal (MOM)

Methoxymethyl aminal (MOM) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • MeOCH2Cl KH (CH2NMe2)2
    THF
    0 °C
    2.5 h
    99 %
    intermediate structure
    KH, (CH2NMe2)2, MeOCH2Cl
    THF
    0 °C, 2.5 h, 99%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • HCl
    THF Et2O H2O
    RT
    5 h
    80 %
    intermediate structure
    HCl
    THF, Et2O, H2O
    RT, 5 h, 80%
    intermediate structure