Benzyl ester

Benzyl ester scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • BnOH TsOH
    PhH
    Reflux
    24 h
    67 %
    intermediate structure
    BnOH, TsOH
    PhH
    Reflux, 24 h, 67%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • H2 Pd/C
    MeOH
    RT
    5 h
    99 %
    intermediate structure
    H2, Pd/C
    MeOH
    RT, 5 h, 99%
    intermediate structure
  • H2 Pd/C
    MeOH EtOAc
    RT
    ON
    100 %
    intermediate structure
    H2, Pd/C
    MeOH, EtOAc
    RT, ON, 100%
    intermediate structure