Trifluoroacetamide

Trifluoroacetamide scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • (CF3CO)2O Pyr
    CH2Cl2
    0 °C - RT
    12.5 h
    74 %
    intermediate structure
    (CF3CO)2O, Pyr
    CH2Cl2
    0 °C to RT, 12.5 h, 74%
    intermediate structure
  • (CF3CO)2O K2CO3
    CHCl3
    RT
    30 min
    79 %
    intermediate structure
    (CF3CO)2O, K2CO3
    CHCl3
    RT, 30 min, 79%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • NaOMe
    CH2Cl2 MeOH
    RT
    60 min
    82 %
    intermediate structure
    NaOMe
    CH2Cl2, MeOH
    RT, 60 min, 82%
    intermediate structure
  • K2CO3
    MeOH H2O
    Reflux
    30 min
    100 %
    intermediate structure
    K2CO3
    MeOH, H2O
    Reflux, 30 min, 100%
    intermediate structure