Benzylamine (Bn)

Benzylamine (Bn) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • BnBr K2CO3
    MeOH
    Reflux
    3 d
    89 %
    intermediate structure
    BnBr, K2CO3
    MeOH
    Reflux, 3 d, 89%
    intermediate structure
  • PhCHO NaBH4 Na2SO4
    EtOH
    -5 - 0 °C
    ON
    90 %
    intermediate structure
    PhCHO, NaBH4, Na2SO4
    EtOH
    -5 to 0 °C, ON, 90%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • H2 Pd/C HCl
    EtOH
    RT
    7 h
    92 %
    intermediate structure
    H2, Pd/C, HCl
    EtOH
    RT, 7 h, 92%
    intermediate structure