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Named Reactions
Protecting Groups
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Named Reactions
Protecting Groups
Benzoate (Bz)
Protection :
Reagents
Solvents
Temperature
Time
Yield
BzCl
Pyr
CH2Cl2
RT
3 h
96 %
info
BzCl
,
Pyr
CH2Cl2
RT, 3 h, 96%
BzCl
Pyr
RT - 70 °C
4 - 24 h
78-90 %
info
BzCl
Pyr
70 °C, 24 h, 78%
info
BzCl
Pyr
RT, 4 h, 90%
BzCl
DMAP
Et3N
CH2Cl2
0 °C - RT
30 min
82 %
info
BzCl
,
DMAP
,
Et3N
CH2Cl2
0 °C to RT, 30 min, 82%
Deprotection :
Reagents
Solvents
Temperature
Time
Yield
K2CO3
MeOH
RT
60 min - 2 h
94-95 %
info
K2CO3
MeOH
RT, 60 min, 94%
info
K2CO3
MeOH
RT, 2 h, 95%
K2CO3
MeOH
THF
RT
2 h
81 %
info
K2CO3
MeOH
,
THF
RT, 2 h, 81%
KOH
EtOH
RT
20 min
80 %
info
KOH
EtOH
RT, 20 min, 80%
KCN
EtOH
0 °C
3 h
68 %
info
KCN
EtOH
0 °C, 3 h, 68%
"76 % yield based on 89 % conversion."