2-Naphthylmethyl ether (Nap)

2-Naphthylmethyl ether (Nap) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • NaH n-Bu4N+ I- 2-Bromomethylnaphthalene
    DMF
    0 °C - RT
    36 h
    96 %
    intermediate structure
    NaH, n-Bu4N+ I-, 2-Bromomethylnaphthalene
    DMF
    0 °C to RT, 36 h, 96%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • DDQ
    CH2Cl2 MeOH
    RT
    60 min
    84 %
    intermediate structure
    DDQ
    CH2Cl2, MeOH
    RT, 60 min, 84%
    intermediate structure