2-Methoxyethoxymethyl ether (MEM)

2-Methoxyethoxymethyl ether (MEM) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • i-Pr2NEt MeO(CH2)2OCH2Cl
    DCE
    80 °C
    13 h
    88 %
    intermediate structure
    i-Pr2NEt, MeO(CH2)2OCH2Cl
    DCE
    80 °C, 13 h, 88%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • ZnBr2
    CH2Cl2
    RT
    2 h
    100 %
    intermediate structure
    ZnBr2
    CH2Cl2
    RT, 2 h, 100%
    intermediate structure