Yamaguchi Esterification

Schematic representation of the Yamaguchi Esterification.
Mechanism of the Yamaguchi Esterification
Mechanism of the Yamaguchi Esterification
Original publication
Review
Sample reactions
intermediate structure
Et3N, DMAP
PhMe
RT, 105 min, 62%
intermediate structure
intermediate structure
DMAP
PhMe
60 to 90 °C, 34 h, 79% (2 steps)
"Ar = 2,4,6-trichlorophenyl"
intermediate structure
intermediate structure intermediate structure
Cs2CO3
PhMe
6 d, 50%
""Heated in a sealed tube"."
intermediate structure
intermediate structure intermediate structure
Et3N, DMAP
THF, PhH
83%
intermediate structure