Weinreb Ketone Synthesis

Schematic representation of the Weinreb Ketone Synthesis.
Mechanism of the Weinreb Ketone Synthesis
Mechanism of the Weinreb Ketone Synthesis
Sample reactions
intermediate structure
VinylMgBr
THF
0 °C, 60 min, 95%
intermediate structure
intermediate structure
AllylMgBr
THF
0 °C, , 93%
intermediate structure
intermediate structure
n-C9H19MgBr
THF
-30 to 0 °C, 60 min, 80%
intermediate structure
intermediate structure intermediate structure
t-BuLi
Et2O
-23 °C, 4.5 h, 52%
intermediate structure
intermediate structure intermediate structure
THF
-78 to 0 °C, 30 min, 71%
intermediate structure