Stille Coupling
Mechanism of the Stille Coupling
Original publication | |
---|---|
Reviews |
Sample reactions
(Me3Sn)2, LiCl, Pd(PPh3)4
THF
60 °C, , 80%
CO, LiCl, Pd2(dba)3, Ph3As
3.5 atm
NMP
70 °C, , 80%
CuCl, Pd(PPh3)4, CuCl2
DMSO
60 °C, 2 h, 82%
LiCl, Pd(PPh3)4
THF
RT, 7 d
n-Bu3SnH, Pd(PPh3)4
THF
RT, 60 min, 86%
Pd(PPh3)4, VinylSnBu3
Dioxane
100 °C, 16 h, 91%
CuCl, LiCl, Pd(PPh3)4
DMSO
RT, 10 min, 53% (3 steps)
CuCl, LiCl, Pd(PPh3)4
DMSO
60 °C, 60 min, 61% (3 steps)
n-Bu3SnH, Pd(PPh3)4
PhMe
RT, 20 min, 88%
i-Pr2NEt, Pd2(dba)3
NMP
RT, 22 h, 62%
Pd(PPh3)4, (n-Bu3Sn)2
PhMe
110 °C, 24 h, 70%
CuI, Pd2(dba)3.CHCl3, Ph3As
DMF
RT, 48 h, 100%
PdCl2.2MeCN
DMF
RT, ON, 68%
Pd(PPh3)2Cl2
DMF
90 °C, 5 h, 74%
Pd2(dba)3, Ph3As, CuBr.Me2S
DMSO, THF
RT, 1 h, 78%
LiCl, Pd2(dba)3, VinylSnBu3, (2-Furyl)3P
NMP
RT, 1 h, 69%
Pd2(dba)3
CH2Cl2
RT, 3 h, 60%