Staudinger Reaction

Mechanism of the Staudinger Reaction

Original publication	Helv. Chim. Acta. 1919, 2, 635. Tetrahedron: Asymmetry. 2016, 27, 91.
Reviews	Angew. Chem. Int. Ed.. 2004, 43, 3106. Tetrahedron. 1981, 37, 473. Tetrahedron. 1992, 48, 1353.

Sample reactions

Ph3P

H2O, THF

RT, 2.5 d

Me3P

H2O, THF

RT to Reflux, 35 min

AcOH, Ph3P

H2O, THF

60 °C, 60 min, 72%

Me3P

H2O, THF

Me3P

H2O, THF