Schotten-Baumann Reaction

Schematic representation of the Schotten-Baumann Reaction.
Mechanism of the Schotten-Baumann Reaction
Mechanism of the Schotten-Baumann Reaction
Sample reactions
intermediate structure
BzCl, K2CO3
CHCl3, H2O
Reflux, 2 h, 96% (2 steps)
intermediate structure
intermediate structure
BzCl, K2CO3
PhH, H2O
RT, 2 h, 84% (2 steps)
intermediate structure
intermediate structure
ClCO2(p-NO2Ph), NaHCO3
CH2Cl2, H2O
RT
intermediate structure
intermediate structure
BzCl, NaOH
H2O
RT to 40 °C, , 70% (2 steps)
intermediate structure
intermediate structure
Ac2O, NaHCO3
CH2Cl2, Hexane(s), H2O
RT, 60 min, 43% (3 steps)
intermediate structure
intermediate structure
ClCO2Me, NaOH, Et3NBn+ Cl-
CH2Cl2, H2O
0 °C, 5 h, 86%
intermediate structure
intermediate structure intermediate structure
NaOH, n-Bu4N+ Cl-
CH2Cl2, H2O
0 °C, 50 min, 86%
intermediate structure
intermediate structure intermediate structure
NaOH
DME, H2O
RT, 10 min, 94%
intermediate structure