Reformatsky Reaction

Mechanism of the Reformatsky Reaction

Original publication	Ber. Dtsch. Chem. Ges.. 1887, 20, 1210. Tetrahedron. 2004, 61, 2713.
Reviews	Angew. Chem. Int. Ed.. 2007, 46, 2568. Org. React.. 1942, 1, 1. Org. React.. 1975, 22, 423. Synthesis. 1989, 0, 571. Tetrahedron. 2004, 60, 9325. Comp. Org. Syn.. 1991, 2, 277.

Sample reactions

SmI2

THF

-78 °C, 20 min, 70%

ZnCl2, Na.Naphthalene

HMPA, THF

0 °C to RT, 9 h, 89%

SiO2, Zn, BrCH2CO2Me

Et2O, PhH

Reflux, 16 h