Overman Rearrangement

Schematic representation of the Overman Rearrangement.
Mechanism of the Overman Rearrangement
Mechanism of the Overman Rearrangement
Sample reactions
intermediate structure
(CF3CO)2O, Et3N, Cl3CCH2OH
CH2Cl2
0 °C to RT, 3.5 h, 87%
intermediate structure
intermediate structure
Na2CO3
o-Xylene
140 °C, 2.5 h, 58% (2 steps)
intermediate structure