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Protecting Groups
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Named Reactions
Protecting Groups
Nozaki-Hiyama-Kishi Reaction
Mechanism of the Nozaki-Hiyama-Kishi Reaction
Original publication
J. Am. Chem. Soc.. 1977, 99, 3179.
J. Am. Chem. Soc.. 1986, 108, 5644.
J. Am. Chem. Soc.. 1986, 108, 6048.
Reviews
Adv. Synth. Catal.. 2007, 349, 240.
Org. React.. 2004, 64, 253.
Sample reactions
info
CrCl2
,
NiCl2
DMF
30% (3 steps)
info
LiAlH4
,
CrCl3
THF
0 °C to RT, 5 h, 30%
"Also isolated was the C2-epimer (47 % yield)."
info
LiAlH4
,
CrCl3
THF
0 °C to RT, 3 h, 81%