Noyori Asymmetric Hydrogenation

Mechanism of the Noyori Asymmetric Hydrogenation

Original publication	J. Am. Chem. Soc.. 1987, 109, 5856.
Reviews	Acc. Chem. Res.. 1990, 23, 345. Acc. Chem. Res.. 1997, 30, 97. Chem. Rev.. 1998, 98, 2599.

Sample reactions

H2, [RuI2(p-cymene)]2, (R)-BINAP

120 atm

CH2Cl2, MeOH

40 °C, 24 h, 95%

2.5 atm

MeOH

RT, , 93%