Nazarov Cyclization Reaction

Mechanism of the Nazarov Cyclization Reaction

Original publication	Izv. Akad. Nauk. SSSR, Ser. Khim.. 1941, 0, 211.
Reviews	Comp. Org. Syn.. 1991, 5, 751. Eur. J. Org. Chem.. 2005, 0, 2193. Org. React.. 1994, 45, 1. Synthesis. 1983, 0, 429. Tetrahedron. 2005, 61, 7577. Tetrahedron. 2005, 61, 6479. Tetrahedron. 2011, 67, 5851.

Sample reactions

H2SO4

90 °C, 4 h

TMSOTf

MeNO2

105 °C, 65 min, 70%

AgBF4

DCE, CH2Cl2

-50 °C to RT, 20 h, 38%

P2O5

MsOH

0 °C, 2 min, 68%