Lombardo Methylenation

Schematic representation of the Lombardo Methylenation.
Mechanism of the Lombardo Methylenation
Mechanism of the Lombardo Methylenation
Sample reactions
intermediate structure
TiCl4, Zn, CH2I2, PbCl2
THF
72%
intermediate structure
intermediate structure
TiCl4, Zn, CH2Br2
CH2Cl2, THF
-40 to 0 °C, 20 h, 98%
intermediate structure