Ley-Griffith Oxidation

Schematic representation of the Ley-Griffith Oxidation.
Mechanism of the Ley-Griffith Oxidation
Mechanism of the Ley-Griffith Oxidation
Original publication
Review
Sample reactions
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 60 min
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 60 min, 86% 2 steps)
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 43 h, 98%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
94%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 5 h, 84% (3 steps)
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 15 min, 100%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
MeCN
RT, 2 h, 95%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
MeCN, CH2Cl2
RT, 2 h, 82%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
MeCN
RT, 2 h, 93%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
0 °C, 30 min, 92%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2, MeCN
0 °C to RT, 60 min, 80%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 60 min, 76%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 2.5 h, 100%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 30 min, 85%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
86%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 60 min
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
0 °C to RT, 20 min
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
CH2Cl2
RT, 90 min, 91%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
MeCN
0 °C to RT, 2.5 h, 80%
intermediate structure
intermediate structure
n-Pr4N+ RuO4-, NMO
MeCN
RT, 75 min, 76% (3 steps)
intermediate structure