Kumada-Corriu Coupling

Schematic representation of the Kumada-Corriu Coupling.
Mechanism of the Kumada-Corriu Coupling
Mechanism of the Kumada-Corriu Coupling
Sample reactions
intermediate structure
TMSCH2MgCl, Pd(PPh3)4
Et2O
RT, 60 min, 91%
intermediate structure
intermediate structure intermediate structure
Pd(PPh3)4
THF
RT, 30 min, 62% (3 steps)
intermediate structure
intermediate structure
TMSCH2MgCl, Pd2(dba)3, t-Bu3P
THF
Reflux, 12 h, 83%
intermediate structure