Friedländer synthesis

Schematic representation of the Friedländer synthesis.
Mechanism of the Friedländer synthesis
Mechanism of the Friedländer synthesis
Sample reactions
intermediate structure intermediate structure
NaOH
MeOH
57 °C, 6 h
intermediate structure
intermediate structure
TsOH
Dean-Stark
PhMe
Reflux, 3 h, 79%
intermediate structure