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Named Reactions
Protecting Groups
Fischer Indole Synthesis
Mechanism of the Fischer Indole Synthesis
Original publication
Ber. Dtsch. Chem. Ges.. 1883, 16, 2241.
Heterocycles. 1984, 22, 1211.
Reviews
Chem. Rev.. 1963, 63, 373.
Chem. Rev.. 1969, 69, 227.
Org. Prep. Proced. Int.. 1993, 25, 607.
Sample reactions
info
PPA
100 °C, 10 min, 54%
info
HCO2H
80 °C, 10 h, 72%
info
AcOH
110 °C, 40 h, 75% (93% BRSM)
info
PhNHNH2
AcOH
95 °C, 8 h, 62%
info
AcOH
EtOH
,
H2O
70 °C, 65 min, 45%