Corey-Posner, Whitesides-House Reaction

Schematic representation of the Corey-Posner, Whitesides-House Reaction.
Mechanism of the Corey-Posner, Whitesides-House Reaction
Mechanism of the Corey-Posner, Whitesides-House Reaction
Sample reactions
intermediate structure
MeLi, CuSCN, MeI
Et2O
-78 to -15 °C, 3.5 h, 72%
intermediate structure
intermediate structure
MeLi, CuI, MeI
Et2O
-45 °C to RT, 13 h, 95%
intermediate structure