Browse by molecules
Browse by principal investigator
Browse by date
Browse by carbon count
menu
Browse Syntheses
arrow_drop_down
Named Reactions
Protecting Groups
Browse Syntheses
arrow_drop_down
Browse by molecules
Browse by principal investigator
Browse by date
Browse by carbon count
Named Reactions
Protecting Groups
Clemmensen Reduction
Mechanism of the Clemmensen Reduction
Original publication
Ber. Dtsch. Chem. Ges.. 1913, 46, 1837.
Reviews
Org. React.. 1942, 1, 155.
Org. React.. 1975, 22, 40.
Sample reactions
info
HCl
,
Zn(Hg)
EtOH
,
H2O
Reflux, 25.5 h, 36% (3 steps)
"Also isolated was the regioisomer (8 % yield)."
info
HCl
,
Zn(Hg)
H2O
,
PhMe
Reflux, 48 h, 83%
info
HCl
,
Zn
,
HgCl2
EtOH
,
H2O
Reflux, 2 h, 88%